Mistral Medium 3 Instruct vs Nemotron 4 340B
Mistral Medium 3 Instruct (2025) and Nemotron 4 340B (2025) are compact production models from MistralAI and NVIDIA AI. Mistral Medium 3 Instruct ships a 128k-token context window, while Nemotron 4 340B ships a 4k-token context window. On pricing, Mistral Medium 3 Instruct costs $0.40/1M input tokens versus $4.20/1M for the alternative. This comparison covers specs, pricing, API access, capabilities, benchmarks, input and output token costs, and production fit for coding and agent workloads.
Mistral Medium 3 Instruct is ~950% cheaper at $0.40/1M; pay for Nemotron 4 340B only for provider fit.
Decision scorecard
Local evidence first| Signal | Mistral Medium 3 Instruct | Nemotron 4 340B |
|---|---|---|
| Best for | multimodal apps and provider-routed production | provider-routed production |
| Decision fit | Long context and Vision | Classification and JSON / Tool use |
| Context window | 128k | 4k |
| Cheapest output | $2/1M tokens | $4.20/1M tokens |
| Provider routes | 2 tracked | 2 tracked |
| Shared benchmarks | 0 rows | 0 rows |
Decision tradeoffs
- Mistral Medium 3 Instruct has the larger context window for long prompts, retrieval packs, or transcript analysis.
- Mistral Medium 3 Instruct has the lower cheapest tracked output price at $2/1M tokens.
- Mistral Medium 3 Instruct uniquely exposes Vision and Multimodal in local model data.
- Local decision data tags Mistral Medium 3 Instruct for Long context and Vision.
- Nemotron 4 340B uniquely exposes Structured outputs in local model data.
- Local decision data tags Nemotron 4 340B for Classification and JSON / Tool use.
Monthly cost at traffic
Estimate token spend from the cheapest tracked input and output route or tier on this page.
Mistral Medium 3 Instruct
$820
Cheapest tracked route/tier: Mistral AI Studio
Nemotron 4 340B
$4,410
Cheapest tracked route/tier: DeepInfra
Estimated monthly gap: $3,590. Batch, cache, alternate speed tiers, and negotiated pricing are excluded from this local estimate.
Switch friction
- Provider overlap exists on NVIDIA NIM; start route-level A/B tests there.
- Nemotron 4 340B is $2.20/1M tokens higher on cheapest tracked output pricing, so quality gains need to justify the spend.
- Check replacement coverage for Vision and Multimodal before moving production traffic.
- Nemotron 4 340B adds Structured outputs in local capability data.
- Provider overlap exists on NVIDIA NIM; start route-level A/B tests there.
- Mistral Medium 3 Instruct is $2.20/1M tokens lower on cheapest tracked output pricing before cache, batch, or negotiated discounts.
- Check replacement coverage for Structured outputs before moving production traffic.
- Mistral Medium 3 Instruct adds Vision and Multimodal in local capability data.
Specs
| Specification | ||
|---|---|---|
| Released | 2025-10-01 | 2025-02-27 |
| Context window | 128k | 4k |
| Parameters | — | 340B |
| Architecture | decoder only | decoder only |
| License | Proprietary | NVIDIA Open Model |
| Openness | Proprietary | Open weights |
| Commercial use | Commercial use with conditions | Commercial use allowed |
| Knowledge cutoff | 2025-03 | - |
Pricing and availability
| Pricing attribute | Mistral Medium 3 Instruct | Nemotron 4 340B |
|---|---|---|
| Input price | $0.40/1M tokens | $4.20/1M tokens |
| Output price | $2/1M tokens | $4.20/1M tokens |
| Providers |
Capabilities
| Capability | Mistral Medium 3 Instruct | Nemotron 4 340B |
|---|---|---|
| Vision | Yes | No |
| Multimodal | Yes | No |
| Reasoning | No | No |
| Function calling | No | No |
| Tool use | No | No |
| Structured outputs | No | Yes |
| Code execution | No | No |
| IDE integration | No | No |
| Computer use | No | No |
| Parallel agents | No | No |
Benchmarks
No shared benchmark rows are currently sourced for this pair.
Deep dive
The capability footprint differs most on vision: Mistral Medium 3 Instruct, multimodal input: Mistral Medium 3 Instruct, and structured outputs: Nemotron 4 340B. Both models share the core language-model surface, so the practical split is not just feature count. Use those differences to decide whether the page is about raw model quality, agentic coding support, multimodal ingestion, or predictable structured API behavior.
For cost, Mistral Medium 3 Instruct lists $0.40/1M input and $2/1M output tokens on the cheapest tracked provider, while Nemotron 4 340B lists $4.20/1M input and $4.20/1M output tokens on the cheapest tracked provider. A 70/30 input-output blend puts Mistral Medium 3 Instruct lower by about $3.32 per million blended tokens. Availability is 2 providers versus 2, so concentration risk also matters.
Choose Mistral Medium 3 Instruct when long-context analysis, larger context windows, and lower input-token cost are central to the workload. Choose Nemotron 4 340B when provider fit are more important. For production, rerun your own prompts through the exact provider, region, and tool stack you plan to ship. This keeps the decision grounded in measurable tradeoffs instead of brand-level assumptions.
FAQ
Which has a larger context window, Mistral Medium 3 Instruct or Nemotron 4 340B?
Mistral Medium 3 Instruct supports 128k tokens, while Nemotron 4 340B supports 4k tokens. That gap matters most for long documents, large codebases, retrieval-heavy agents, and conversations where earlier context must remain visible.
Which is cheaper, Mistral Medium 3 Instruct or Nemotron 4 340B?
Mistral Medium 3 Instruct is cheaper on tracked token pricing. Mistral Medium 3 Instruct costs $0.40/1M input and $2/1M output tokens. Nemotron 4 340B costs $4.20/1M input and $4.20/1M output tokens. Provider discounts or batch pricing can still change the final bill.
Is Mistral Medium 3 Instruct or Nemotron 4 340B open source?
Mistral Medium 3 Instruct is listed under Proprietary. Nemotron 4 340B is listed under NVIDIA Open Model. License labels affect whether you can self-host, redistribute weights, or rely only on hosted APIs, so confirm the upstream license before deployment.
Which is better for vision, Mistral Medium 3 Instruct or Nemotron 4 340B?
Mistral Medium 3 Instruct has the clearer documented vision signal in this comparison. If vision is mission-critical, validate it against the provider endpoint because model-level support and API-level exposure can differ.
Which is better for multimodal input, Mistral Medium 3 Instruct or Nemotron 4 340B?
Mistral Medium 3 Instruct has the clearer documented multimodal input signal in this comparison. If multimodal input is mission-critical, validate it against the provider endpoint because model-level support and API-level exposure can differ.
Where can I run Mistral Medium 3 Instruct and Nemotron 4 340B?
Mistral Medium 3 Instruct is available on NVIDIA NIM and Mistral AI Studio. Nemotron 4 340B is available on NVIDIA NIM and DeepInfra. Provider coverage can affect latency, region availability, compliance posture, and fallback options.
Continue comparing
Last reviewed: 2026-06-04. Data sourced from public model cards and provider documentation.