Claude Opus 4.5 vs Qwen2.5-72B
Claude Opus 4.5 (2025) and Qwen2.5-72B (2025) are frontier reasoning models from Anthropic and Alibaba. Claude Opus 4.5 ships a 200k-token context window, while Qwen2.5-72B ships a 128k-token context window. On MMLU PRO, Claude Opus 4.5 leads by 16.9 pts. This comparison covers specs, pricing, API access, capabilities, benchmarks, input and output token costs, and production fit for coding and agent workloads.
Claude Opus 4.5 is safer overall; choose Qwen2.5-72B when provider fit matters.
Decision scorecard
Local evidence first| Signal | Claude Opus 4.5 | Qwen2.5-72B |
|---|---|---|
| Best for | reasoning-heavy apps, multimodal apps, and tool-calling agents | tool-calling agents |
| Decision fit | Coding, RAG, and Agents | RAG, Agents, and Long context |
| Context window | 200k | 128k |
| Cheapest output | $25/1M tokens | - |
| Provider routes | 6 tracked | 0 tracked |
| Shared benchmarks | MMLU PRO leader | 1 shared |
Decision tradeoffs
- Claude Opus 4.5 holds a shared-benchmark lead on MMLU PRO, ahead by 16.9 points.
- Claude Opus 4.5 has the larger context window for long prompts, retrieval packs, or transcript analysis.
- Claude Opus 4.5 has broader tracked provider coverage for fallback and route flexibility.
- Claude Opus 4.5 uniquely exposes Vision, Multimodal, and Reasoning in local model data.
- Local decision data tags Claude Opus 4.5 for Coding, RAG, and Agents.
- Local decision data tags Qwen2.5-72B for RAG, Agents, and Long context.
Monthly cost at traffic
Estimate token spend from the cheapest tracked input and output route or tier on this page.
Claude Opus 4.5
$10,250
Cheapest tracked route/tier: Microsoft Foundry
Qwen2.5-72B
Unavailable
No complete token price in local provider data
Cost delta unavailable until both models have sourced input and output token prices.
Switch friction
- No overlapping tracked provider route is sourced for Claude Opus 4.5 and Qwen2.5-72B; plan for SDK, billing, or endpoint changes.
- Check replacement coverage for Vision, Multimodal, and Reasoning before moving production traffic.
- No overlapping tracked provider route is sourced for Qwen2.5-72B and Claude Opus 4.5; plan for SDK, billing, or endpoint changes.
- Claude Opus 4.5 adds Vision, Multimodal, and Reasoning in local capability data.
Specs
| Specification | ||
|---|---|---|
| Released | 2025-11-01 | 2025-10-10 |
| Context window | 200k | 128k |
| Parameters | — | 72B |
| Architecture | Decoder Only | - |
| License | Proprietary | Apache 2.0OSI-approved |
| Openness | Proprietary | Open source |
| Weights | Not released | Available |
| Code | Unknown | Unknown |
| Commercial use | Commercial use: conditional | Commercial use: permitted |
| Knowledge cutoff | 2025-12 | 2024-09 |
Pricing and availability
| Pricing attribute | Claude Opus 4.5 | Qwen2.5-72B |
|---|---|---|
| Input price | $5/1M tokens | - |
| Output price | $25/1M tokens | - |
| Providers | - |
Capabilities
| Capability | Claude Opus 4.5 | Qwen2.5-72B |
|---|---|---|
| Vision | Yes | No |
| Multimodal | Yes | No |
| Reasoning | Yes | No |
| JSON / Tool use | Yes | Yes |
| Structured outputs | Yes | No |
| Code execution | Yes | No |
| IDE integration | No | No |
| Computer use | No | No |
| Parallel agents | No | No |
Benchmarks
| Benchmark | Claude Opus 4.5 | Qwen2.5-72B |
|---|---|---|
| MMLU PRO | 88.9 | 72.0 |
Continue comparing
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Last reviewed: 2026-07-26. Data sourced from public model cards and provider documentation.