GPT-5.4 Pro vs Mixtral 8x22B Instruct v0.3
GPT-5.4 Pro (2026) and Mixtral 8x22B Instruct v0.3 (2024) are frontier reasoning models from OpenAI and MistralAI. GPT-5.4 Pro ships a 1.05m-token context window, while Mixtral 8x22B Instruct v0.3 ships a 64k-token context window. On pricing, GPT-5.4 Pro ranges from $30 to $60/1M input tokens by tier; Mixtral 8x22B Instruct v0.3 costs $2/1M input tokens. This comparison covers specs, pricing, API access, capabilities, benchmarks, input and output token costs, and production fit for coding and agent workloads.
GPT-5.4 Pro fits 16x more tokens; pick it for long-context work and Mixtral 8x22B Instruct v0.3 for tighter calls.
Decision scorecard
Local evidence first| Signal | GPT-5.4 Pro | Mixtral 8x22B Instruct v0.3 |
|---|---|---|
| Best for | reasoning-heavy apps, multimodal apps, and tool-calling agents | tool-calling agents |
| Decision fit | Coding, RAG, and Agents | Agents and JSON / Tool use |
| Context window | 1.05m | 64k |
| Cheapest output | $180/1M tokens | $2/1M tokens |
| Provider routes | 3 tracked | 1 tracked |
| Shared benchmarks | 0 rows | 0 rows |
Decision tradeoffs
- GPT-5.4 Pro has the larger context window for long prompts, retrieval packs, or transcript analysis.
- GPT-5.4 Pro has broader tracked provider coverage for fallback and procurement flexibility.
- GPT-5.4 Pro uniquely exposes Vision, Multimodal, and Reasoning in local model data.
- Local decision data tags GPT-5.4 Pro for Coding, RAG, and Agents.
- Mixtral 8x22B Instruct v0.3 has the lower cheapest tracked output price at $2/1M tokens.
- Local decision data tags Mixtral 8x22B Instruct v0.3 for Agents and JSON / Tool use.
Monthly cost at traffic
Estimate token spend from the cheapest tracked input and output route or tier on this page.
GPT-5.4 Pro
$69,000
Cheapest tracked route/tier: OpenRouter
Mixtral 8x22B Instruct v0.3
$2,100
Cheapest tracked route/tier: Replicate API
Estimated monthly gap: $66,900. Batch, cache, alternate speed tiers, and negotiated pricing are excluded from this local estimate.
Switch friction
- No overlapping tracked provider route is sourced for GPT-5.4 Pro and Mixtral 8x22B Instruct v0.3; plan for SDK, billing, or endpoint changes.
- Mixtral 8x22B Instruct v0.3 is $178/1M tokens lower on cheapest tracked output pricing before cache, batch, or negotiated discounts.
- Check replacement coverage for Vision, Multimodal, and Reasoning before moving production traffic.
- No overlapping tracked provider route is sourced for Mixtral 8x22B Instruct v0.3 and GPT-5.4 Pro; plan for SDK, billing, or endpoint changes.
- GPT-5.4 Pro is $178/1M tokens higher on cheapest tracked output pricing, so quality gains need to justify the spend.
- GPT-5.4 Pro adds Vision, Multimodal, and Reasoning in local capability data.
Specs
| Specification | ||
|---|---|---|
| Released | 2026-03-01 | 2024-07-01 |
| Context window | 1.05m | 64k |
| Parameters | — | 8x22B |
| Architecture | decoder only | mixture of experts |
| License | Proprietary | Apache 2.0(OSI) |
| Openness | Proprietary | Open source |
| Commercial use | Commercial use with conditions | Commercial use allowed |
| Knowledge cutoff | 2025-08 | 2024-01 |
Pricing and availability
| Pricing attribute | GPT-5.4 Pro | Mixtral 8x22B Instruct v0.3 |
|---|---|---|
| Input price |
| $2/1M tokens |
| Output price |
| $2/1M tokens |
| Providers |
Capabilities
| Capability | GPT-5.4 Pro | Mixtral 8x22B Instruct v0.3 |
|---|---|---|
| Vision | Yes | No |
| Multimodal | Yes | No |
| Reasoning | Yes | No |
| Function calling | Yes | Yes |
| Tool use | Yes | No |
| Structured outputs | Yes | No |
| Code execution | Yes | No |
| IDE integration | No | No |
| Computer use | No | No |
| Parallel agents | No | No |
Benchmarks
No shared benchmark rows are currently sourced for this pair.
Deep dive
The capability footprint differs most on vision: GPT-5.4 Pro, multimodal input: GPT-5.4 Pro, reasoning mode: GPT-5.4 Pro, tool use: GPT-5.4 Pro, structured outputs: GPT-5.4 Pro, and code execution: GPT-5.4 Pro. Both models share function calling, so the practical split is not just feature count. Use those differences to decide whether the page is about raw model quality, agentic coding support, multimodal ingestion, or predictable structured API behavior.
For cost, GPT-5.4 Pro lists tiered pricing: 0-272,000t is $30/1M input and $180/1M output; 272,000t+ is $60/1M input and $270/1M output, while Mixtral 8x22B Instruct v0.3 lists $2/1M input and $2/1M output tokens on the cheapest tracked provider. A 70/30 input-output blend puts Mixtral 8x22B Instruct v0.3 lower by about $73 per million blended tokens. For tiered rows, this cheapest-track view can understate interactive or fast-lane spend, so compare the tier you will actually use. Availability is 3 providers versus 1, so concentration risk also matters.
Choose GPT-5.4 Pro when coding workflow support, larger context windows, and broader provider choice are central to the workload. Choose Mixtral 8x22B Instruct v0.3 when provider fit and lower input-token cost are more important. For production, rerun your own prompts through the exact provider, region, and tool stack you plan to ship.
FAQ
Which has a larger context window, GPT-5.4 Pro or Mixtral 8x22B Instruct v0.3?
GPT-5.4 Pro supports 1.05m tokens, while Mixtral 8x22B Instruct v0.3 supports 64k tokens. That gap matters most for long documents, large codebases, retrieval-heavy agents, and conversations where earlier context must remain visible.
Which is cheaper, GPT-5.4 Pro or Mixtral 8x22B Instruct v0.3?
GPT-5.4 Pro lists tiered pricing: 0-272,000t is $30/1M input and $180/1M output; 272,000t+ is $60/1M input and $270/1M output. Mixtral 8x22B Instruct v0.3 lists $2/1M input and $2/1M output tokens on the cheapest tracked provider. Compare the tier you will actually use; cheap async pricing can overstate savings for interactive workflows. Provider discounts or batch pricing can still change the final bill.
Is GPT-5.4 Pro or Mixtral 8x22B Instruct v0.3 open source?
GPT-5.4 Pro is listed under Proprietary. Mixtral 8x22B Instruct v0.3 is listed under Apache 2.0. License labels affect whether you can self-host, redistribute weights, or rely only on hosted APIs, so confirm the upstream license before deployment.
Which is better for vision, GPT-5.4 Pro or Mixtral 8x22B Instruct v0.3?
GPT-5.4 Pro has the clearer documented vision signal in this comparison. If vision is mission-critical, validate it against the provider endpoint because model-level support and API-level exposure can differ. Use this as a quick comparison signal, then confirm the provider-specific limits before committing to production.
Which is better for multimodal input, GPT-5.4 Pro or Mixtral 8x22B Instruct v0.3?
GPT-5.4 Pro has the clearer documented multimodal input signal in this comparison. If multimodal input is mission-critical, validate it against the provider endpoint because model-level support and API-level exposure can differ.
Where can I run GPT-5.4 Pro and Mixtral 8x22B Instruct v0.3?
GPT-5.4 Pro is available on OpenRouter, OpenAI API, and Vercel AI Gateway. Mixtral 8x22B Instruct v0.3 is available on Replicate API. Provider coverage can affect latency, region availability, compliance posture, and fallback options.
Continue comparing
Last reviewed: 2026-05-22. Data sourced from public model cards and provider documentation.