GPT-5.4 vs Qwen2.5-72B-Instruct
GPT-5.4 (2026) and Qwen2.5-72B-Instruct (2024) are frontier reasoning models from OpenAI and Alibaba. GPT-5.4 ships a 1.05m-token context window, while Qwen2.5-72B-Instruct ships a 128k-token context window. On Google-Proof Q&A, GPT-5.4 leads by 53.6 pts. On pricing, GPT-5.4 ranges from $2.50 to $5/1M input tokens by tier; Qwen2.5-72B-Instruct costs $0.18/1M input tokens. This comparison covers specs, pricing, API access, capabilities, benchmarks, input and output token costs, and production fit for coding and agent workloads.
GPT-5.4 fits 8x more tokens; pick it for long-context work and Qwen2.5-72B-Instruct for tighter calls.
Decision scorecard
Local evidence first| Signal | GPT-5.4 | Qwen2.5-72B-Instruct |
|---|---|---|
| Best for | reasoning-heavy apps, multimodal apps, and tool-calling agents | provider-routed production |
| Decision fit | Coding, RAG, and Agents | Coding, RAG, and Long context |
| Context window | 1.05m | 128k |
| Cheapest output | $15/1M tokens | $0.54/1M tokens |
| Provider routes | 3 tracked | 7 tracked |
| Shared benchmarks | Google-Proof Q&A leader | 2 rows |
Decision tradeoffs
- GPT-5.4 holds a shared-benchmark lead on Google-Proof Q&A, ahead by 53.6 points.
- GPT-5.4 has the larger context window for long prompts, retrieval packs, or transcript analysis.
- GPT-5.4 uniquely exposes Vision, Multimodal, and Reasoning in local model data.
- Local decision data tags GPT-5.4 for Coding, RAG, and Agents.
- Qwen2.5-72B-Instruct has the lower cheapest tracked output price at $0.54/1M tokens.
- Qwen2.5-72B-Instruct has broader tracked provider coverage for fallback and procurement flexibility.
- Local decision data tags Qwen2.5-72B-Instruct for Coding, RAG, and Long context.
Monthly cost at traffic
Estimate token spend from the cheapest tracked input and output route or tier on this page.
GPT-5.4
$5,750
Cheapest tracked route/tier: OpenAI API
Qwen2.5-72B-Instruct
$279
Cheapest tracked route/tier: Chutes AI
Estimated monthly gap: $5,471. Batch, cache, alternate speed tiers, and negotiated pricing are excluded from this local estimate.
Switch friction
- Provider overlap exists on OpenRouter; start route-level A/B tests there.
- Qwen2.5-72B-Instruct is $14.46/1M tokens lower on cheapest tracked output pricing before cache, batch, or negotiated discounts.
- Check replacement coverage for Vision, Multimodal, and Reasoning before moving production traffic.
- Provider overlap exists on OpenRouter; start route-level A/B tests there.
- GPT-5.4 is $14.46/1M tokens higher on cheapest tracked output pricing, so quality gains need to justify the spend.
- GPT-5.4 adds Vision, Multimodal, and Reasoning in local capability data.
Specs
| Specification | ||
|---|---|---|
| Released | 2026-03-05 | 2024-06-07 |
| Context window | 1.05m | 128k |
| Parameters | — | 72.7B |
| Architecture | decoder only | decoder only |
| License | Proprietary | Apache 2.0(OSI) |
| Openness | Proprietary | Open source |
| Commercial use | Commercial use with conditions | Commercial use allowed |
| Knowledge cutoff | 2025-08 | - |
Pricing and availability
| Pricing attribute | GPT-5.4 | Qwen2.5-72B-Instruct |
|---|---|---|
| Input price |
| $0.18/1M tokens |
| Output price |
| $0.54/1M tokens |
| Providers |
Capabilities
| Capability | GPT-5.4 | Qwen2.5-72B-Instruct |
|---|---|---|
| Vision | Yes | No |
| Multimodal | Yes | No |
| Reasoning | Yes | No |
| Function calling | Yes | No |
| Tool use | Yes | No |
| Structured outputs | Yes | Yes |
| Code execution | Yes | No |
| IDE integration | No | No |
| Computer use | No | No |
| Parallel agents | No | No |
Benchmarks
| Benchmark | GPT-5.4 | Qwen2.5-72B-Instruct |
|---|---|---|
| Google-Proof Q&A | 92.0 | 38.4 |
| Chatbot Arena | 1479.0 | 1270.0 |
Deep dive
On shared benchmark coverage, Google-Proof Q&A has GPT-5.4 at 92 and Qwen2.5-72B-Instruct at 38.4, with GPT-5.4 ahead by 53.6 points; Chatbot Arena has GPT-5.4 at 1479 and Qwen2.5-72B-Instruct at 1270, with GPT-5.4 ahead by 209 points. The largest visible gap is 209 points on Chatbot Arena, which matters most when that benchmark mirrors your workload. Treat isolated benchmark wins as directional, because provider routing, prompt style, and tool access can move real application results.
The capability footprint differs most on vision: GPT-5.4, multimodal input: GPT-5.4, reasoning mode: GPT-5.4, function calling: GPT-5.4, tool use: GPT-5.4, and code execution: GPT-5.4. Both models share structured outputs, so the practical split is not just feature count. Use those differences to decide whether the page is about raw model quality, agentic coding support, multimodal ingestion, or predictable structured API behavior.
For cost, GPT-5.4 lists tiered pricing: 0-272,000t is $2.50/1M input and $15/1M output; 272,000t+ is $5/1M input and $22.50/1M output, while Qwen2.5-72B-Instruct lists $0.18/1M input and $0.54/1M output tokens on the cheapest tracked provider. A 70/30 input-output blend puts Qwen2.5-72B-Instruct lower by about $5.96 per million blended tokens. For tiered rows, this cheapest-track view can understate interactive or fast-lane spend, so compare the tier you will actually use. Availability is 3 providers versus 7, so concentration risk also matters.
Choose GPT-5.4 when coding workflow support and larger context windows are central to the workload. Choose Qwen2.5-72B-Instruct when provider fit, lower input-token cost, and broader provider choice are more important. For production, rerun your own prompts through the exact provider, region, and tool stack you plan to ship.
FAQ
Which has a larger context window, GPT-5.4 or Qwen2.5-72B-Instruct?
GPT-5.4 supports 1.05m tokens, while Qwen2.5-72B-Instruct supports 128k tokens. That gap matters most for long documents, large codebases, retrieval-heavy agents, and conversations where earlier context must remain visible. Use this as a quick comparison signal, then confirm the provider-specific limits before committing to production.
Which is cheaper, GPT-5.4 or Qwen2.5-72B-Instruct?
GPT-5.4 lists tiered pricing: 0-272,000t is $2.50/1M input and $15/1M output; 272,000t+ is $5/1M input and $22.50/1M output. Qwen2.5-72B-Instruct lists $0.18/1M input and $0.54/1M output tokens on the cheapest tracked provider. Compare the tier you will actually use; cheap async pricing can overstate savings for interactive workflows. Provider discounts or batch pricing can still change the final bill.
Is GPT-5.4 or Qwen2.5-72B-Instruct open source?
GPT-5.4 is listed under Proprietary. Qwen2.5-72B-Instruct is listed under Apache 2.0. License labels affect whether you can self-host, redistribute weights, or rely only on hosted APIs, so confirm the upstream license before deployment.
Which is better for vision, GPT-5.4 or Qwen2.5-72B-Instruct?
GPT-5.4 has the clearer documented vision signal in this comparison. If vision is mission-critical, validate it against the provider endpoint because model-level support and API-level exposure can differ. Use this as a quick comparison signal, then confirm the provider-specific limits before committing to production.
Which is better for multimodal input, GPT-5.4 or Qwen2.5-72B-Instruct?
GPT-5.4 has the clearer documented multimodal input signal in this comparison. If multimodal input is mission-critical, validate it against the provider endpoint because model-level support and API-level exposure can differ.
Where can I run GPT-5.4 and Qwen2.5-72B-Instruct?
GPT-5.4 is available on OpenAI API, OpenRouter, and Vercel AI Gateway. Qwen2.5-72B-Instruct is available on DeepInfra, OpenRouter, Fireworks AI, Novita AI, and Chutes AI. Provider coverage can affect latency, region availability, compliance posture, and fallback options.
Continue comparing
Last reviewed: 2026-06-04. Data sourced from public model cards and provider documentation.